MetrumRG scientists announced as ACoP10 Quality Award winner!

Posted by Shona Kidd on Jul 24, 2019 3:25:07 PM

MetrumRG scientists will be presenting a poster at ACoP10 this fall titled "Model-based Dose Selection for a GnRH Receptor Antagonist in Endometriosis and Uterine Fibroids (UF) to Reduce Symptoms While Preventing Lumbar Spine Bone Mineral Density (BMD) Loss". It was announced today that the poster will be honored as an ACoP10 Quality Award Winner for outstanding use of quantitative methods to advance drug development. Authors of the poster are: Kyle Baron, Oliver Pohl, Matthew Riggs, Jonathan French, Jean-Pierre Gotteland, and Ramon Garcia. Be sure to check back with us after the event to see the poster in the Publications section of our website

If you are attending ACoP10 this year, please stop by our booth and say hi! As a reminder, registration is open now and space is going quick!

MetrumRG will also be presenting two workshops at ACoP10. 

The first is a one-day workshop entitled  “Introduction to Bayesian pharmacometric data analysis with NONMEM” on Saturday 19 October 2019. In this workshop, we will introduce principles and methods of Bayesian data analysis for pharmacometric applications.  We will provide a guided hands-on experience in Bayesian data analysis using NONMEM v7.4. The hands-on examples will focus on population PK and PK/PD models with specific attention to situations when informative prior distributions can be used to reflect pharmacological understanding.  The course will cover basic Bayesian and Markov chain Monte Carlo methodology, methods for model evaluation and MCMC convergence, and tips for implementation of models in NONMEM.  The course will end with an introduction to fitting Bayesian population PK and PK/PD models with Stan/Torsten.

The second is a one-and-a-half-day workshop entitled “Simulation Concepts and their Application to Model-Informed Drug Development.” on Thursday and Friday, October 24-25, 2019. This hands-on workshop will provide participants with a foundation for applying simulation to decision-making in the drug development process.  The workshop will begin with a discussion of how to translate key questions into quantitative decision criteria, suitable to be addressed through simulation.  This will be followed by an introduction to mrgsolve, an open-source platform for simulation in R (, and a discussion of fundamental simulation concepts, such as how to implement uncertainty and variability to produce appropriate simulation output.  Finally, the workshop will wrap up with hands-on case studies in mrgsolve, allowing the students to implement what they’ve learned.

You can register for the workshops via your ACoP registration. Looking forward to a great meeting this fall! 

Topics: Bone Health, Metrum News

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