News

Modeling methods for analyzing tumor dynamic data from basket trials

Posted by Alanna S. Ocampo-Pelland on Oct 18, 2017 9:01:02 AM

Poster presented by Alanna S. Ocampo-Pelland and Jonathan L. French at ACoP8. See the poster here

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Topics: Methodology, Tools, and Computation, Oncology, Open Science

Cloud Computing at ACoP

Posted by Tim Bergsma on May 31, 2017 3:54:23 PM

by Tim Bergsma

Already widely received in the finance community, cloud computing is gaining acceptance in the pharmaceutical industry as well. At this year’s American Conference on Pharmacometrics, Metrum Research Group staff presented a poster on the topic, and helped lead a related panel discussion.

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Topics: Methodology, Tools, and Computation

Adding Sinew to Roxygen Skeletons

Posted by Yoni Sidi on May 31, 2017 3:52:45 PM

For new developers, getting a package ready for building and submitting to CRAN is an expletive-filled, head-scratching experience to say the least. Trying to figure out the basics of what goes in depends and what goes in imports is a lost afternoon most of us would like back. Once that is understood, filling in relevant information to each field is a mundane task even for a well polished package developer. The out-of-the-box roxygen skeleton supplied by RStudio gives the bare bones road map of what should be part of function documentation:

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Topics: Methodology, Tools, and Computation

PaSiPhIC Conference

Posted by Jonathan French on May 31, 2017 3:51:13 PM

Recently, I was asked to speak at this year’s PaSiPhIC conference about different approaches to meta-analysis. As I was putting together my presentation, I began to wonder: How can we best leverage traditional meta-analysis methods in a model-based drug development framework?

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Topics: Methodology, Tools, and Computation

Metrum Research Group Presents at Bio-IT World 2012

Posted by Jeffrey Hane on May 31, 2017 3:47:52 PM
Jeff Hane of MetrumRG and Adam Kraut of The BioTeam presented details of MetrumRG’s ground-breaking infrastructure in the cloud at Bio-IT World 2012 (Boston, MA). The talk, ‘Building A Scalable Pharmacometrics Platform in the Cloud’, was delivered in the Cloud Computing Track on April 25. Grab your copy of the slide deck today.
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Topics: Methodology, Tools, and Computation, Metrum News

What Decisions Benefit from Model-Based Meta-Analysis (MBMA)?

Posted by Jeffrey Hane on May 31, 2017 3:47:13 PM

The primary rationale for model-based meta-analysis (MBMA) is to improve decision-making by better leveraging prior information from multiple sources. Decision-makers generally attempt to consider such prior information, but it is usually done in a relatively qualitative manner, and each individual decision-maker is usually aware of only a subset of the prior information. MBMA seeks to make the process more quantitative and comprehensive. The process and results of MBMA may be made visible (aka transparent) to the decision-makers. The end result is that the decision-makers are better informed, and they can contribute their knowledge to the modeling process leading to better, more trusted models and model-based inferences.

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Topics: Methodology, Tools, and Computation

Can methods based on existing models really aid decision making in non-small-cell lung cancer (NSCLC) trials?

Posted by Jonathan French on May 31, 2017 3:46:34 PM

I recently returned from the 2013 PAGE meeting in Glasgow. As usual, the scientific presentations were some of the best in the field of pharmacometrics. At this year’s meeting I was offered an opportunity to present some of our recent thoughts about model-based drug development in oncology.

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Topics: Methodology, Tools, and Computation, Oncology

Practice of Bayesian Analysis

Posted by Charles Margossian on May 19, 2017 2:31:50 PM

 

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Topics: Methodology, Tools, and Computation, Neurodegenerative Diseases

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