MetrumRG scientists attended and presented at the 2019 Joint Statistical Meetings (JSM) in Denver, CO. JSM is renowned as the largest gathering of statisticians and data scientists held in North America.

On Thursday, Michael Heathman, M.S., presented "Integration of Pharmacometrics and Statistics to Support Study Design Optimization".

MetrumRG scientists will be presenting a poster at ACoP10 this fall titled "Model-based Dose Selection for a GnRH Receptor Antagonist in Endometriosis and Uterine Fibroids (UF) to Reduce Symptoms While Preventing Lumbar Spine Bone Mineral Density (BMD) Loss". It was announced today that the poster will be honored as an ACoP10 Quality Award Winner for outstanding use of quantitative methods to advance drug development. Authors of the poster are: Kyle Baron, Oliver Pohl, Matthew Riggs, Jonathan French, Jean-Pierre Gotteland, and Ramon Garcia. Be sure to check back with us after the event to see the poster in the Publications section of our website. 

Metrum Research Group scientists participated in the first International Society of Pharmacometrics (ISoP) Regional Quantitative Systems Pharmacology (QSP) Day on July 16, 2019. 

The meeting, which included podium presentations, a poster session, and opportunities for discussion and networking, highlighted several examples of the application of QSP methods in drug development. Particularly notable topics included: the integration of transcriptomics and systems pharmacology models, challenges with calibration of virtual patients in QSP models, and the use of QSP as a scaffold for bridging from well studied therapeutic indications to related but somewhat less understood indications.

Madeleine Gastonguay, of MetrumRG and University of Connecticut, presented the poster "Development of an open-source physiologically-based pharmacokinetic model to predict maternal-fetal exposures of CYP450-metabolized drugs". The open science philosophy, exemplified in this work, resonated with attendees and was also highlighted by several of the conference speakers.

Special thanks goes to the meeting organizers, the ISoP QSP Special Interest Group (ISoP QSP SIG), and hosts, Bristol-Myers Squibb (BMS), for a well organized event and an energizing, thought-provoking day.

Pictures from the event below.

Metrum Research Group staff and families recently participated the Alzheimer’s Association The Longest Day fundraiser. This initiative took place on June 21st, the summer solstice, the day with the most daylight. The goal of this day was to come together to fight the darkness of Alzheimer’s disease. Our employees participated in recognition of the many people we know who have been affected by this disease and also to acknowledge the contributions MetrumRG has made to help fight for a cure (some of this work can be seen here). Participants donated and joined in for a fun evening of playing games together. The game night theme symbolized the effort of keeping the brain active. The event resulted in a nice donation for the Alzheimer’s Association and a fun evening by all who attended.

Read the latest news, events, and publications from Metrum Research Group in our Summer 2019 Newsletter.

Here’s what you will find in our newsletter:  

• MetrumRG now offers Clinical Pharmacology and Drug Development Strategy consulting services!
• Find out more about our new team members!
• A list of upcoming events our scientists will be attending or presenting at!
• Publications and presentations by MetrumRG scientists!

MetrumRG scientists traveled to Stockholm, Sweden to join the Population Approach Group in Europe for their 2019 annual meeting in June.

MetrumRG employees recognized Rare Disease Day on February 28th by participating in the National Organization for Rare Disorder’s Show Your Stripes campaign. While we work every day to develop therapies to fight disease, for the month of February we challenged employees and heightened awareness by highlighting different rare diseases in weekly meetings. On February 28th, we shared a pot luck lunch with a striped food theme and dressed to show off our stripes. MetrumRG employees across the country participated. We had a contest to see who had the best display of stripes and Metrum Research Group pledged a donation for each person that  participated in the stripes challenge. Check out the photos below of our day of recognition!

Metrum Research Group is raising awareness of Rare Disease Day during the entire month of February. Rare Disease Day occurs on February 28, 2019. The National Organization for Rare Disorders has issued a challenge to participate in recognizing rare diseases by showing your stripes, as the zebra is the official symbol of rare diseases in the United States. We have invited our employees to participate in a Show Your Stripes Challenge in the following ways:

Click here to read the latest news from Metrum Research Group.

The following is a transcription of Dr. Gastonguay's acceptance speech when presented with the 2018 Bristol-Myers Squibb Mentorship in Clinical Pharmacology Award at the American College of Clinical Pharmacology on September 24, 2018.

Open Science: A Key to the Future Growth of Clinical Pharmacology.