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ISoP Regional QSP Day 2019

Posted by Marc Gastonguay on Jul 17, 2019 11:41:15 AM

Metrum Research Group scientists participated in the first International Society of Pharmacometrics (ISoP) Regional Quantitative Systems Pharmacology (QSP) Day on July 16, 2019. 

The meeting, which included podium presentations, a poster session, and opportunities for discussion and networking, highlighted several examples of the application of QSP methods in drug development. Particularly notable topics included: the integration of transcriptomics and systems pharmacology models, challenges with calibration of virtual patients in QSP models, and the use of QSP as a scaffold for bridging from well studied therapeutic indications to related but somewhat less understood indications.

Madeleine Gastonguay, of MetrumRG and University of Connecticut, presented the poster "Development of an open-source physiologically-based pharmacokinetic model to predict maternal-fetal exposures of CYP450-metabolized drugs". The open science philosophy, exemplified in this work, resonated with attendees and was also highlighted by several of the conference speakers.

Special thanks goes to the meeting organizers, the ISoP QSP Special Interest Group (ISoP QSP SIG), and hosts, Bristol-Myers Squibb (BMS), for a well organized event and an energizing, thought-provoking day.

Pictures from the event below.

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Topics: Methodology, Tools, and Computation, Open Science

Marc R. Gastonguay, Ph.D., awarded 2018 Bristol-Myers Squibb Mentorship in Clinical Pharmacology Award

Posted by Marc Gastonguay on Oct 10, 2018 3:59:21 PM

The following is a transcription of Dr. Gastonguay's acceptance speech when presented with the 2018 Bristol-Myers Squibb Mentorship in Clinical Pharmacology Award at the American College of Clinical Pharmacology on September 24, 2018.

Open Science: A Key to the Future Growth of Clinical Pharmacology.

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Topics: Open Science

Modeling methods for analyzing tumor dynamic data from basket trials

Posted by Alanna S. Ocampo-Pelland on Oct 18, 2017 9:01:02 AM

Poster presented by Alanna S. Ocampo-Pelland and Jonathan L. French at ACoP8. See the poster here

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Topics: Methodology, Tools, and Computation, Oncology, Open Science

Gaining Efficiency by Combining Analytical and Numerical Methods to Solve ODEs: Implementation in Stan and Application to Bayesian PK/PD Modeling

Posted by William R. Gillespie on Oct 17, 2017 9:30:12 AM
Poster presented at ACoP8 by  Charles C. Margossian  and William R. Gillespie. Check it out here
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Topics: Open Science

Slides available: Points to Consider when Making Inferences about Covariates

Posted by Marc Gastonguay on Oct 16, 2017 11:45:00 AM
Click here to access the slides from " Points to Consider when Making Inferences about Covariates" presented by Marc Gastonguay, Ph.D. at ACoP8 Session Quantification of Covariate Effects for Labeling. 
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Topics: Open Science

Theory, Empiricism, and a Vision for the Continued Growth of Pharmacometrics

Posted by Marc Gastonguay on Oct 15, 2017 11:17:16 PM

Slides Available: Dr. Marc Gastonguay's Sheiner Award lecture presented at ACoP8 on October 15, 2017. GastonguayISoPSheinerLecture2017final

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Topics: Open Science

An ODE to Open Science

Posted by Matthew M. Riggs, Ph.D. on Sep 29, 2017 8:05:00 AM

Developing quantitative systems pharmacology (QSP) models is hard work, without doubt. Such projects often take months, if not years, and may include extensive experimental contributions and input from numerous discipline experts.

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Topics: Open Science

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