MetrumRG Fall Community Outreach Efforts

Posted by Diane Reynolds on Dec 18, 2019 7:30:25 AM

The fall season brought several opportunities for MetrumRG employees to give to local communities.

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Topics: Community Outreach

MetrumRG at ACoP 2019

Posted by Diane Reynolds on Nov 19, 2019 12:58:45 PM

MetrumRG scientists traveled to Orlando, FL to join the American Conference on Pharmacometrics for their 2019 annual meeting in October.

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Topics: Metrum News

MetrumRG Fall 2019 Newsletter

Posted by Heidi Seaborg on Oct 2, 2019 1:28:51 PM


Read the latest news, events, and publications from Metrum Research Group in our Fall 2019 Newsletter.

Here’s what you will find in our newsletter:  

  • MetrumRG at ACoP10: Our workshops, presentations, and posters!
  • Announcement about our newest team members!
  • Upcoming events our scientists will be attending or presenting at.
  • Publications and presentations by MetrumRG scientists.
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Topics: Metrum News

MetrumRG at Walk MS

Posted by Diane Reynolds on Sep 20, 2019 11:20:56 AM


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Topics: Community Outreach

Proposal for an Open Software Development Life Cycle

Posted by Marc Gastonguay on Sep 16, 2019 2:31:04 PM

The confluence of several factors, including: the growing recognition of the value of quantitative approaches to decision-making in drug development, advancements in numerical methods and analytics, and democratization of modern software engineering, has led to the emergence of multiple pharmacometrics-related software tools, both commercially and publicly licensed. A rigorously managed, high-quality, software development practice is central to reliable and reproducible scientific application and regulatory compliance for these tools. Professional software development best practices should typically be outlined in a Software Development Life Cycle (SDLC) policy or procedure, but the extent of guidance, consistency of methods, adherence to procedures, completeness of quality documentation, and execution rigor vary greatly across software development organizations or teams.

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Topics: Methodology, Tools, and Computation, Open Science

MetrumRG at R/Pharma

Posted by Michelle Johnson on Aug 28, 2019 4:08:50 PM

August 21-23, 2019

MetrumRG scientists visited Harvard University to participate in the R/Pharma conference.

This was the second annual R/Pharma conference, which included keynotes from renowned industry practitioners, key R developers, and leading academics. There were also several full-length presentations as well as a number of shorter, highly-energetic lightning talks. And new this year, pre-conference workshops were offered to the 150 attendees. MetrumRG was honored to deliver three presentations and to support the event again this year by hosting a mixer on Thursday night. Congratulations to the organizing committee for another successful R/Pharma!

Here is a recap of our MetrumRG presentations:

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Where to find MetrumRG in August!

Posted by Shona Kidd on Aug 12, 2019 8:09:18 AM

Our scientists are attending and presenting at many conferences in August. Here's where you can find them:

Read on for more information:

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Topics: Metrum News

MetrumRG at JSM2019 in Denver, CO

Posted by Shona Kidd on Aug 2, 2019 1:55:53 PM

MetrumRG scientists attended and presented at the 2019 Joint Statistical Meetings (JSM) in Denver, CO. JSM is renowned as the largest gathering of statisticians and data scientists held in North America.

On Thursday, Michael Heathman, M.S., presented "Integration of Pharmacometrics and Statistics to Support Study Design Optimization".

For more pictures, read on!
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Topics: Metrum News

MetrumRG scientists announced as ACoP10 Quality Award winner!

Posted by Shona Kidd on Jul 24, 2019 3:25:07 PM

MetrumRG scientists will be presenting a poster at ACoP10 this fall titled "Model-based Dose Selection for a GnRH Receptor Antagonist in Endometriosis and Uterine Fibroids (UF) to Reduce Symptoms While Preventing Lumbar Spine Bone Mineral Density (BMD) Loss". It was announced today that the poster will be honored as an ACoP10 Quality Award Winner for outstanding use of quantitative methods to advance drug development. Authors of the poster are: Kyle Baron, Oliver Pohl, Matthew Riggs, Jonathan French, Jean-Pierre Gotteland, and Ramon Garcia. Be sure to check back with us after the event to see the poster in the Publications section of our website

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Topics: Bone Health, Metrum News

ISoP Regional QSP Day 2019

Posted by Marc Gastonguay on Jul 17, 2019 11:41:15 AM

Metrum Research Group scientists participated in the first International Society of Pharmacometrics (ISoP) Regional Quantitative Systems Pharmacology (QSP) Day on July 16, 2019. 

The meeting, which included podium presentations, a poster session, and opportunities for discussion and networking, highlighted several examples of the application of QSP methods in drug development. Particularly notable topics included: the integration of transcriptomics and systems pharmacology models, challenges with calibration of virtual patients in QSP models, and the use of QSP as a scaffold for bridging from well studied therapeutic indications to related but somewhat less understood indications.

Madeleine Gastonguay, of MetrumRG and University of Connecticut, presented the poster "Development of an open-source physiologically-based pharmacokinetic model to predict maternal-fetal exposures of CYP450-metabolized drugs". The open science philosophy, exemplified in this work, resonated with attendees and was also highlighted by several of the conference speakers.

Special thanks goes to the meeting organizers, the ISoP QSP Special Interest Group (ISoP QSP SIG), and hosts, Bristol-Myers Squibb (BMS), for a well organized event and an energizing, thought-provoking day.

Pictures from the event below.

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Topics: Methodology, Tools, and Computation, Open Science

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