Metrum Research Group Announces New President

Posted by Michelle Johnson on May 31, 2017 3:55:03 PM

Metrum Research Group is pleased to announce the appointment of Bill Knebel, Pharm.D., Ph.D. as President of the biomedical modeling and simulation services firm.

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Topics: Metrum News

Cloud Computing at ACoP

Posted by Tim Bergsma on May 31, 2017 3:54:23 PM

by Tim Bergsma

Already widely received in the finance community, cloud computing is gaining acceptance in the pharmaceutical industry as well. At this year’s American Conference on Pharmacometrics, Metrum Research Group staff presented a poster on the topic, and helped lead a related panel discussion.

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Topics: Methodology, Tools, and Computation

Alzheimer’s Association International Conference

Posted by Jim Rogers on May 31, 2017 3:53:20 PM

“Prevention … we have never uttered that word at the Alzheimer’s Association International Conference, and here we actually highlighted three clinical trials in the planning for prevention of Alzheimer’s … “. This comment from Dr. Mario Carrillo gives voice to the enthusiasm and interest of the attendees at the standing-room-only Alzheimer’s Association International Conference session entitled, “Collaboration for Alzheimer’s Prevention: Common Issues Across Presymptomatic Treatment Trials”, in which the A4, API, and DIAN prevention trials were discussed.

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Topics: Neurodegenerative Diseases

Adding Sinew to Roxygen Skeletons

Posted by Yoni Sidi on May 31, 2017 3:52:45 PM

For new developers, getting a package ready for building and submitting to CRAN is an expletive-filled, head-scratching experience to say the least. Trying to figure out the basics of what goes in depends and what goes in imports is a lost afternoon most of us would like back. Once that is understood, filling in relevant information to each field is a mundane task even for a well polished package developer. The out-of-the-box roxygen skeleton supplied by RStudio gives the bare bones road map of what should be part of function documentation:

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Topics: Methodology, Tools, and Computation

Hepatitis C Viral Dynamic Modeling and Clinical Pharmacology

Posted by Kyle Baron on May 31, 2017 3:51:56 PM

An article in the recent issue of Heptaology illustrates an insightful application of hepatitis C viral dynamic modeling and clinical pharmacology. Guedj et al. (Hepatology 2012 55: 1030-1037) present an HCV dynamic model of viral load versus time during mericitabine therapy. Rather than seeing the clear bi-phasic viral load profile we see with interferon and the protease inhibitors (with characteristic sharp initial drop in viral load), the viral load decline during mericitabine therapy is more complicated: either a slower bi-phasic profile or mono-phasic profile. The authors propose an interesting modeling solution to gain insight into mericitabine’s antiviral activity.

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Topics: Infectious Diseases

PaSiPhIC Conference

Posted by Jonathan French on May 31, 2017 3:51:13 PM

Recently, I was asked to speak at this year’s PaSiPhIC conference about different approaches to meta-analysis. As I was putting together my presentation, I began to wonder: How can we best leverage traditional meta-analysis methods in a model-based drug development framework?

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Topics: Methodology, Tools, and Computation

Metrum Research Group Presents at PAGE 2012

Posted by Michelle Johnson on May 31, 2017 3:48:45 PM

by Mary Delaney

Last week, Bill Gillespie and Elodie Plan journeyed to Venice, Italy representing Metrum Research Group at the Population Approach Group Europe (PAGE 2012) meeting. Bill and Elodie presented posters of their recent work and communicated the features of METAMODL ( to conference goers.

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Topics: Metrum News

Metrum Research Group Presents at Bio-IT World 2012

Posted by Jeffrey Hane on May 31, 2017 3:47:52 PM
Jeff Hane of MetrumRG and Adam Kraut of The BioTeam presented details of MetrumRG’s ground-breaking infrastructure in the cloud at Bio-IT World 2012 (Boston, MA). The talk, ‘Building A Scalable Pharmacometrics Platform in the Cloud’, was delivered in the Cloud Computing Track on April 25. Grab your copy of the slide deck today.
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Topics: Methodology, Tools, and Computation, Metrum News

What Decisions Benefit from Model-Based Meta-Analysis (MBMA)?

Posted by Jeffrey Hane on May 31, 2017 3:47:13 PM

The primary rationale for model-based meta-analysis (MBMA) is to improve decision-making by better leveraging prior information from multiple sources. Decision-makers generally attempt to consider such prior information, but it is usually done in a relatively qualitative manner, and each individual decision-maker is usually aware of only a subset of the prior information. MBMA seeks to make the process more quantitative and comprehensive. The process and results of MBMA may be made visible (aka transparent) to the decision-makers. The end result is that the decision-makers are better informed, and they can contribute their knowledge to the modeling process leading to better, more trusted models and model-based inferences.

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Topics: Methodology, Tools, and Computation

Can methods based on existing models really aid decision making in non-small-cell lung cancer (NSCLC) trials?

Posted by Jonathan French on May 31, 2017 3:46:34 PM

I recently returned from the 2013 PAGE meeting in Glasgow. As usual, the scientific presentations were some of the best in the field of pharmacometrics. At this year’s meeting I was offered an opportunity to present some of our recent thoughts about model-based drug development in oncology.

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Topics: Methodology, Tools, and Computation, Oncology

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