--- title: Metrum News | Kyle Baron --- [![Metrum research group](https://news.metrumrg.com/hs-fs/hubfs/Metrum%20-April2017/images/logo.png?width=235&height=55&name=logo.png "logo.png")](https://www.metrumrg.com/) [![](https://news.metrumrg.com/hs-fs/hubfs/Metrum%20-April2017/images/footer-logo%20(1).png?width=137&height=33&name=footer-logo%20(1).png "logo.png")](https://www.metrumrg.com/) [Contact](https://info.metrumrg.com/contact) - [About](https://www.metrumrg.com/about/) - [Services](https://www.metrumrg.com/services/) - [Metworx](https://www.metrumrg.com/solution/metworx/) - [Open Science](https://www.metrumrg.com/open-science/) - [Publications](https://www.metrumrg.com/publications/) - [Blog](https://news.metrumrg.com/blog) - [Events](https://www.metrumrg.com/events/) - [Careers](https://www.metrumrg.com/careers/) - [About](https://www.metrumrg.com/about/) - [Services](https://www.metrumrg.com/services/) - [Metworx](https://www.metrumrg.com/solution/metworx/) - [Open Science](https://www.metrumrg.com/open-science/) - [Publications](https://www.metrumrg.com/publications/) - [Blog](https://news.metrumrg.com/blog) - [Events](https://www.metrumrg.com/events/) - [Careers](https://www.metrumrg.com/careers/) Enter Search Item Enter Search Item # News ## Kyle Baron ### Recent Posts ## [Hepatitis C Viral Dynamic Modeling and Clinical Pharmacology](https://news.metrumrg.com/blog/hepatitis-c-viral-dynamic-modeling-and-clinical-pharmacology) Posted by [Kyle Baron](https://news.metrumrg.com/blog/author/kyle-baron) on May 31, 2017, 3:51:56 PM - [Tweet](https://twitter.com/share) An article in the recent issue of Heptaology illustrates an insightful application of hepatitis C viral dynamic modeling and clinical pharmacology. Guedj et al. (Hepatology 2012 55: 1030-1037) present an HCV dynamic model of viral load versus time during mericitabine therapy. Rather than seeing the clear bi-phasic viral load profile we see with interferon and the protease inhibitors (with characteristic sharp initial drop in viral load), the viral load decline during mericitabine therapy is more complicated: either a slower bi-phasic profile or mono-phasic profile. The authors propose an interesting modeling solution to gain insight into mericitabine’s antiviral activity. [Read More](https://news.metrumrg.com/blog/hepatitis-c-viral-dynamic-modeling-and-clinical-pharmacology) 0 Comments [Click here to read/write comments](https://news.metrumrg.com/blog/hepatitis-c-viral-dynamic-modeling-and-clinical-pharmacology#comments-listing) Topics: [Infectious Diseases](https://news.metrumrg.com/blog/topic/infectious-diseases) [All posts](https://news.metrumrg.com/blog/all) ## We love to share! 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